The highway is closed going in both directions.
The incident happened at about 5:45 a.m. and a motorist in a Toyota 4-Runner was hit by the slide causing major damage to the vehicle, but no injuries were reported.
The slide happened just east of Echo Summit.
CalTrans is working to open Johnson Pass Road to through traffic but there is no estimation on when it will be open. Eastbound traffic is being stopped and turned around at Sierra-at-Tahoe.
The estimated time to open the road is four to six hours, CHP said in a social media post.
Travelers are advised to use alternate routes such as Highway 88 over Carson Pass or Interstate 80 over Donner Summit.